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KMID : 0848020020050010052
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Journal of Korean Breast Cancer Society
2002 Volume.5 No. 1 p.52 ~ p.58
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Distribution and Prognostic Effect on Adjuvant Hormone Therapy of Body Mass Index (BMI) in Korean Breast Cancer Patients
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민연기/Youn Ki Min
박중민/김완배/조성진/김애리/김남렬/조민영/정석인/배정원/구범환/Choong Min Park/Wan Bae Kim/Sung Jin Cho/Ae Ree Kim/Nam Ryeol Kim/Min Young Cho/Suk In Jung/Jeoung Won Bae/Bum Hwan Koo
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Abstract
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Purpose: Obesity has been shown to have important effects related to breast cancer. But there have been few data available on the distribution of body mass index (BMI) among Korean breast cancer patients and on the effects of this
distribution on
patient prognosis. Therefore we investigated the BMI distribution of Korean breast cancer patient's and its relationship with other tumor markers, in order to elucidate the relationship between BMI and patient prognosis.
Methods: We measured the BMI of 266 Korean adult women with breast carcinoma.and divided the subjects into the following subgroups according to BMI; low body weight (BMI＜20), normal body weight (BMI; 20∼25) and over weight (BMI≥25). We
compared this distribution with that of the general Korean women's population. and investigated the correlation with other prognostic factors and tumor markers. The 5 year overall and disease free survival rates were evaluated for both the total
breast
cancer patients and the adjuvant hormone treated breast cancer patients, according to BMI subgroup, using the Kaplan-Meier method.
Results: Mean BMI for the breast patients was 23.4±3.1, and did not differ from that of the general Korean adult women's population ('1994 National Nutrition Survey Report). BMI increased with increasing age and was highest in the 60∼69
yr
age
group. BMI was correlated with tumor size and stage. The survival rates were low in the high BMI group among both total and adjuvant hormone treated breast cancer patients, but in neither was any statistical difference found between BMI
subgroups.
Conclusion: Korean breast cancer patients are not obese as the general population and their BMI increases with increasing age and menopausal status. There was a tendency for higher BMI to be associated with poorer prognosis, although not
to
a
statistically significant degree.
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KEYWORD
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